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Thrombin-activatable fibrinolysis inhibitor

作者:LUO HUA   发布时间:2012-09-18 08:00:52   浏览次数:545
Thrombin-activatable fibrinolysis inhibitor:
a new modulator linking coagulation and fibrinolysis
 
1.LUO Hua,2.LIANG Ying,
(1.Department of  CCM, Shenzhen Hospital,PKU; 2.Department of Pulmonary Medicine, Beijing Anzhen Hospital, Affiliated Hospital of Capital University of Medical Science, Beijing 100029,China)
 
 
Abstract: Thrombin-activatable fibrinolysis inhibitor (TAFI), as a modulator between coagulation and fibrinolysis, is one of highlight of medical research in the last 10 years. Research on TAFI is an important supplement to classical knowledge connecting the coagulation and fibrinolytic cascades. TAFI is converted into activated TAFI (TAFIa) by thrombin, thrombomodulin, heparin and trypsin in vivo. TAFIa can inhibit fibrinolysis , prolong thrombolytic time and so may increase the risk of thrombosis. TAFI is also involved with modulation of the active substances such as bradykinin and complement. Inhibitor of TAFI was used to treat the thrombosis with fibrinolytic agent on animal models and the effect is good. The relationship between TAFI and diseases of hematological system, cardiovascular system, endocrine system and so on have been widely studied currently.
 
Key words: Thrombin;Thromboembolism; Heparin; Fibrinolysis






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