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Study of relationship among heparin dosage,concent

作者:Hua Luo   发布时间:2012-09-18 08:35:32   浏览次数:592

Study of relationship among heparin dosage,concentration and APTT in pulmonary thromboembolism

 

    LUO Hua,LIANG Ying.ICU of  Shenzhen Hospital of Peking University,Shenzhen 518036,China
 
    [Abstract]  Objective  By using 13u/h/kg of heparin as initial dosage to treat  PTE and  study linear relationship among heparin dosage,concentration and APTT respectively.To predict maintenance dosage,concentration of heparin and APTT range within the therapeutic area depending on regression formula.Methods  In 25 PTE cases,the numerus of APTT and heparin concentration before therapy and every 6 h after therapy were recorded sequently.The linear relationship between heparin concentration and APTT,between heparin dosage and APTT were analyzed separately with correlation and univariate linear regression.Results  ①Linear relationship between heparin concentration and APTT was showed as followP<0.05):The regression formula were APTT=132.99×(heparin concentration)+35.11,lgAPTT=0.599×(heparin concentration)+1.671,heparin concentration=0.0045×APTT-0.055 and heparin concentration=0.874×lgAPTT-1.260.②Linear relationship between heparin dosage and concentration was found as follow:nearly all of coefficients of correlation and determination between individual and within individual were P>0.05.The linear regression formula of single factor with statistics significance could not been found.③Linear relationship between heparin dosage and APTT was examined as follow: the regression formula were APTT=2.72×(heparin dosage)+35.265(P=0.003)and heparin dosage =0.0144×APTT+10.356(P=0.003).Conclusion  ①There are good positive correlation and linear ralationship between heparin concentration(anti Ⅱ factor method)and APTT,which make APTT as a substitution for heparin concentration measurement in clinical practice.Heparin concentration in effective anticoagulation range predicted by regression equation are 0.152~0.260 u/ml(linear)and  0.130~0.300u/ml(lg)respectively.②The relationship among heparin dosage,concentration and APTT are affected by multiple factors.Linear regression of single factor is not enough to reveal properly the relationship between heparin dosage and concentration.
    [Key words]  heparin;APTT;pulmonary thrombo embolism;anticoagulation therapy






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